Providing the measurement infrastructure to allow quantitative diagnostic methods for biomarkers of coronary heart diseases

Short Name: CardioMet, Project Number: 18HLT10
Image of red blood cells blocking an artery
3D rendered image of coronary heart disease

New procedures to enable more accurate diagnostic methods for cardiac disease biomarkers

Heart diseases are a major healthcare challenge in the EU. Cardiovascular disease, for instance, presents around 11 million new cases a year and is a factor in around 1.8 million deaths. Laboratory tests of certain biomarkers are used to guide treatments, but reliability is compromised by variation in results between tests, even for the same markers of disease. For example, the absence of agreed reference materials or procedures for cardiac troponin I (a marker for heart attacks) results in 85 % measurement variation between different test kits. However, traceable reference methods for the main biomarkers would substantially improve test performance and comparability.


The project has characterised and developed measurement procedures to enable traceable quantification of relevant biomarkers with the support of the most significant standards making organisations. It also developed a biosensor probe for faster diagnosis of heart attacks, and promoted the methods developed to laboratories, medical device makers, and medical associations. Reliable quantification of cardiac markers will reduce the risk of incorrect diagnoses, reduce the chance of patient deaths and help lower healthcare costs.


Project website
Other Participants
Academisch Ziekenhuis Leiden (Netherlands)
Assistance publique – Hôpitaux de Paris (France)
Greater Glasgow Health Board (United Kingdom)
Inst Cardiometabolisme Nutrition ICAN (France)
Johann Wolfgang Goethe-Universität Frankfurt am Main (Germany)
Stiftung für Pathobiochemie und Molekulare Diagnostik (Germany)
Uppsala Universitet (Sweden)