Traceability of Complex Biomolecules and Biomarkers in Diagnostics - Effecting Measurement Comparability in Clinical Medicine
Short Name: CLINBIOTRACE, Project Number: T2.J.11Complex biomolecules such as proteins have additional chemical and plasma-based heterogeneity so the concept of "a unique, homogeneous chemical entity" does not apply, few reference measurement methods exist, and the measurands are difficult to define.
This challenging project takes the first steps towards addressing the SI /IU debate by investigating novel methods for linking structural and functional ("activity") SI traceable measurements to the amount of protein present. If this can be realised, it will represent a very considerable advance in measurement science, providing a route to traceable complex protein measurements that will impact significantly on healthcare measurement comparability.
Journal of Mass Spectrometry
Analytcial Biochemistry
Clinical Chemistry
Molecular BioSystems
Analytcial Biochemistry
Analytcial Biochemistry