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Model Peptides Uncover the Role of the β‑Secretase Transmembrane Sequence in Metal Ion Mediated Oligomerization

Munter, Lisa M. (McGill University,Department of Pharmacology and Therapeutics,Freie Universität Berlin,Institut für Chemie und Biochemie,), Sieg, Holger (Freie Universität Berlin, Institut für Chemie und Biochemie), Bethge, Tobias (Freie Universität Berlin, Institut für Chemie und Biochemie,), Liebsch, Filip (McGill University), Bierkandt, Frank S. (BAM Federal Institute for Materials Research and Testing,), Schleeger, Michael (Freie Universität Berlin,Experimental Molecular Biophysics,), Bittner, Heiko J. (Charité,Institut für Medizinische Physik und Biophysik,), Heberle, Joachim (Freie Universität Berlin,Experimental Molecular Biophysics,), Jakubowski, Norbert (BAM Federal Institute for Materials Research and Testing), Hildebrand, Peter W. (Charité,Institut für Medizinische Physik und Biophysik,) and Multhaup, Gerd (McGill University,Department of Pharmacology and Therapeutics,Freie Universität Berlin,Institut für Chemie und Biochemie,)
Keywords:

Alzheimer disease; Amyloid formation; Copper; Enzymes

Document typeArticle
Journal title / SourceJournal of the Americal Chemical Society
Peer-reviewed articleYes
Volume135
Issue51
Page numbers / Article number19354–19361
Publisher's nameACS Publications
Publisher's address (city only)Washington
Publication date 2013-12-4
ISSN0002-7863, 1520-5126
DOI10.1021/ja410812r
Web URLhttp://pubs.acs.org/doi/abs/10.1021/ja410812r
LanguageEnglish

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