Case Studies

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Image showing abstract nanoparticle structure

Measuring nanoparticle shell thickness

Nanoparticles are becoming increasingly used in a wide range of areas, and thus are expected to soon have a significant economic and environmental impact. In health they are used for targeted drug delivery, and in the energy sector they are used in photovoltaic technologies to improve solar cell efficiency compared to conventio...

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Six pictures showing a human brain scan. Three images in upper row showing black and white pictures of the brain and below these the corresponding EPT images in green with orange indicating tissue sub-types

Quantifying the uncertainty of Electric Properties Tomography in medical imaging

Magnetic Resonance Imaging (MRI) is a diagnostic, mainly qualitative, technique used to visualise the soft tissues of a patient. The application of a strong magnetic field causes the protons in a patient’s hydrogen atoms to align with it. Radiofrequency pulses are then used to force the protons to move out of and back into alig...

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Artists impression showing a close up of three pale DNA strands against a dark blue background. The centre strand is being impacted and damaged by a bright beam of light

Simulating the effectiveness of radiotherapy at the nanometre scale

One in two people will develop cancer in their lifetime. Radiotherapy, using external sources of radiation, is a common treatment approach. This includes photon sources, such as x-rays and γ-rays, and particles, such as electrons, protons, and carbon ions. Radiation doses must be carefully calculated – too high a level and heal...

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New reference material for light scatter-based sizing of extracellular vesicles

Extracellular vesicles (EVs) are biological nanoparticles actively released by cells, comprising of an outer lipid membrane, and containing markers indicative of the cell of origin, and housing an inner aqueous core. Most EVs are 100 nm in diameter or less but can range in size from 30 nm to a few micrometres. EVs are found in ...

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Ensuring the accuracy of breath analysers to enforce drink driving regulations

Since 1938, when the first instrument for detecting alcohol in breath was developed, the ‘breathanalyser’ has become increasingly sophisticated. These instruments determine if a person has potentially consumed alcohol by measuring the concentration of ethanol in air exhaled from their lungs. They are now used by law enforcement...

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An improved method for studying nanometre-sized biological particles

Extracellular vesicles (EVs) are small membrane-coated particles (30 nm - 1,000 nm) released from animal and plant cells. Originally thought to be unwanted cellular debris it has since been realised these are actively secreted, contain soluble molecules such as proteins and nucleic acids, and are involved in both normal and pat...

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